Pharmacokinetics and metabolism

What is drug metabolism: drug metabolism is defined as the process of converting from drugs in a typical water connection by simply increasing the drug polarity. Drug metabolism process is necessary for the human body to dilute the drugs in body fluids specified tasks of cells. After dilution of the drugs, their functionality is gone be in water-soluble State transformed and excreted. The metabolism process liver play an important role in carrying out many functions in the body such as the decomposition of red blood cells, glycogen storage, hormone production, plasma protein synthesis, and detoxification of drugs. Liver adds easily connect alkaline digestion process and also bile with support of lipids we free dietary intake.
Liver is the main site for the occurrence of drug metabolism includes all necessary enzymes to help this process and supports many biochemical reactions, which are necessary for metabolism. Cytochrome is the main enzyme group, which includes the process of drug metabolism. This enzyme groups are stored in the cell’s endoplasmic membrane.
Drug metabolism is divided into two phases.
Phase 1 drug metabolism: drug metabolism is usually oxidation and hydrolysis. In phase-1-oxidation biochemical process is done as a routine. Oxidation process will cause catalyzed by the p450cytochrome some electron enzymes, to lose the drug to make chemical reactions in the cell bodies of living organisms. After this phase – 1-process is the drug is completely oxidized and absorbed yet still active in the State, since it is not from the liquid.
Phase 2 drug metabolism: In phase 2 drug metabolism is connected to the drug with an outer ionized group of glutathione and acetyl methyl group. This second phase usually occurs in the cytoplasm of hepatocytes of the cell membrane. The drug metabolite is more water soluble connection due to plant of the ionized group. This process creates activity prior to the release of the reduction of the drug.
Take, for example, the drug metabolism process for aspirin. During the first phase, aspirin through the process of hydrolysis in salicylic acid is converted. And in the second phase, making it acid with glycine a group of ionized metabolic pathways was …nach reacted the drug loses its activity and excreted in the urine.
Hepatitis causes drugs in overdose, is how the presence of glutathione in small quantities, to detoxify the metabolites. So use the prescribed medications appropriately
What does pharmacokinetics: Pharmacokinetics is nothing more than a scientific study of how the body responds to the drugs that we record. It is also known as the study of the movement of drugs in our body.Pharmacokinetics also deals with the investigation of the drug absorption rate, dilution rate, metabolism, and excretion.